Subjects who are at least 18 years of age at time of consent

Subject must be able to give signed, written informed consent

Subject has cardiovascular disease

Subject has a history of major surgery within 4 weeks of screening

Women who are pregnant

Subjects will be asked about any medications or treatments they have taken in the past, or are currently taking, including previous cancer treatments, prescription medications, over-the-counter medications, vitamins, herbal supplements, natural remedies, and radiation therapy. Some medications or treatments the subject has taken may make it difficult for the subject to take part in the study. All medications will have to be reviewed by the study doctor, who may ask the subject to stop some of them. The subject will also be asked about any surgical or invasive treatments they have received within the past 4 weeks. Throughout the study, the subject will be asked to report any changes in their medications or treatments, including for their cancer diagnosis.

Tests and procedures that are done only because the subject is in the study are provided at no cost. This includes:

• Biopsy (if done only for the study)
• OncoSignature Testing
• Extra MRI or CT scans
• Blood sampling for Biomarker Research and for Study Medical Measurements
• Electrocardiograms that would not have been done if the subject were not on the study

The study drugs that are required by the study are provided at no cost to you.

The subject will not be paid for being in this study.

The main purpose of this study is to investigate how effective the study drug is in treating ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma.